Webrns in california earn an average of $133,340 annually, the highest in the nation, and enjoy a positive job outlook. Learn how education, experience, location, and other factors. Webregistered nurses in california earn an average of $124,000 per year or $59. 62 per hour. The percentage of u. s. Registered nurses who work in california is. Webfind out the average hourly and annual salaries of registered nurses, nurse practitioners, certified nurse midwives, certified registered nurse anesthetists, and. Webthe latest data from the u. s. Bureau of labor statistics shows that the difference between the highest and lowest rn salaries is nearly $100,000 in the u. s. Webthe registered nurse salary in california is $125,340 per year. This means that nurses in california earn an average of $60. 26 per hour. On the other hand, the national average.